27 May 2011

PROTEIN VISUALIZATION TOOL-RASMOL



aimTo visualize protein structure using RASMOL


INTRODUCTION:
RasMol is a computer program written for molecular graphics visualization intended and used primarily for the depiction and exploration of biological macromolecule structures, such as those found in the Protein Data Bank. It was originally developed by Roger Sayle in the early 90s.Historically it was an important tool for molecular biologists. Before RasMol, visualization software ran on graphics workstations that, due to their expense, were less accessible to scholars. RasMol has become an important educational tool as well as continuing to be an important tool for research in structural biology.RasMol has a complex version history. Starting with the series of 2.7 versions, RasMol is licensed under a dual license (GPL or custom license RASLIC). RasMol includes a language (for selecting certain protein chains, or changing colors etc). Jmol and Sirius has incorporated the RasMol scripting language into its commands. Protein Databank (PDB) files can be downloaded for visualization from the Research Collaborators for Structural Bioinformatics (RCSB) bank. These have been uploaded by researchers who have characterized the structure of molecules usually by X-ray crystallography or NMR spectroscopy.
PROCEDURE:
·         Enter into the PDB structural database to retrieve the required protein structure.
·         Download the PDB structure obtained.
·         Open the retrieved PDB structure in RASMOL.
·         Interpretation of results.

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