11 Mar 2012

Robert T. Clubb Summary

Robert T. Clubb

Department  of Chemistry & Biochemistry, UCLA

Professor of Biochemisty

B.S.,  University of Wisconsin; Ph.D., University of Michigan; Leukemia Society of America Postdoctoral Fellow; Intramural National Institutes of Health Postdoctoral Fellow; Member of the UCLA-DOE Laboratory of Structural Biology and Molecular Medicine; Member of the Molecular Biology Institute

Clubb Research Overview

My lab investigates the particular molecular groundwork connected with bacterial pathogenesis. We examine exactly how microbes display and also assemble cell wall attached surface proteins, in addition to the way they acquire essential nutrients off their host throughout infections. Inhibitors of these functions could function as effective antimicrobial brokers since they would deprive pathogens of their virulence qualities. We have been especially enthusiastic about your virulence mechanisms utilized by Staphylococcus aureus as it is a leading root cause of life-threatening hospital and community acquired bacterial infections in the united states (1-3). Brand-new drugs are needed to help battle that microbe because remarkably virulent multi-drug methicillin-resistant strains connected with S. Aureus (MRSA) are actually endemic. Each of our key analysis application is usually multi-dimensional heteronuclear nuclear magnetic resonance (NMR) spectroscopy, that's accustomed to research the actual structure and characteristics connected with proteins in addition to his or her complexes with solution. We also employ X-ray crystallography, high-throughput drug screening, cellular, biochemical and bioinformatic strategies.

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