14 Jul 2011

Acute myeloid leukemia

Acute myelogenous leukemia; AML; Acute granulocytic leukemia; Acute nonlymphocytic leukemia (ANLL); Leukemia - acute myeloid (AML); Leukemia - acute granulocytic; Leukemia - nonlymphocytic (ANLL)

Acute myeloid leukemia (AML) is cancer that starts inside bone marrow, the soft tissue inside bones that helps form blood cells. The cancer grows from cells that would normally turn into white blood cells.
Acute means the disease develops quickly.
Causes, occurrence, and risk factors
Acute myeloid leukemia (AML) is one of the most common types of leukemia among adults. This type of cancer is rare under age 40. It generally occurs around age 60. (This article focuses on AML in adults.)
AML is more common in men than women.
Persons with this type of cancer have abnormal cells inside their bone marrow. The cells grow very fast, and replace healthy blood cells. The bone marrow, which helps the body fight infections, eventually stops working correctly. Persons with AML become more prone to infections and have an increased risk for bleeding as the numbers of healthy blood cells decrease.
Most of the time, a doctor cannot tell you what caused AML. However, the following things are thought to lead to some types of leukemia, including AML:
    Certain chemicals (for example, benzene)
    Certain chemotherapy drugs, including etoposide and drugs known as alkylating agents
Problems with your genes may also play a role in the development of AML.
You have an increased risk for AML if you have or had any of the following:
    A weakened immune system (immunosuppression) due to an organ transplant
    Blood disorders, including
        Polycythemia vera
        Essential thrombocythemia
        Myelodysplasia (refractory anemia)
    Exposure to radiation and chemicals
    Bleeding from the nose
    Bleeding gums
    Bone pain or tenderness
    Heavy menstrual periods
    Shortness of breath (gets worse with exercise)
    Skin rash or lesion
    Swollen gums (rare)
    Weight loss
Cipher and tests
The doctor will perform a physical exam. There may be signs of a swollen spleen, liver, or lymph nodes.
A complete blood count (CBC) shows anemia and a low number of platelets. A white blood cell count (WBC) can be high, low, or normal.
Bone marrow aspiration will show if there are any leukemia cells.
If your doctor learns you do have this type of leukemia, further tests will be done to determine the specific type of AML. There are eight subtypes of AML. They range from M0 to M7, based on which blood cells are abnormal.
Action - Treatment
Treatment involves using medicines to kill the cancer cells. This is called chemotherapy. But chemotherapy kills normal cells, too. This may cause side effects such as excessive bleeding and an increased risk for infection. Your doctor may want to keep you away from other people to prevent infection.
Other treatments for AML may include:
    Antibiotics to treat infection
    Bone marrow transplant or stem cell transplant after radiation and chemotherapy
    Red blood cell transfusions to fight anemia
    Transfusions of platelets to control bleeding
Most types of AML are treated the same way. However, a form of AML called acute promyelocytic leukemia (APL) is treated with a medicine called all-trans retinoic acid (ATRA). This medicine helps leukemia cells grow into normal white blood cells.
The drug arsenic trioxide is for use in patients with APL who do not get better with ATRA or chemotherapy.
1.            Appelbaum FM. The acute leukemias. In Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: Chap 194.

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